Job Description

Madrigal Pharmaceuticals seeks a Senior Biostatistician to support clinical development and real-world evidence generation for metabolic liver disease therapeutics. The role involves statistical modeling, biomarker strategy, causal inference, and clinical trial analysis, reporting to the VP of Biostatistics.

Responsibilities

• Develop and apply statistical and machine-learning models to high-dimensional data for biomarker and clinical evidence generation
• Generate real-world evidence from observational data using causal-inference methods
• Support design and analysis of clinical trials and real-world data; contribute to protocols and Statistical Analysis Plans
• Partner with translational science and clinical research teams; contribute to publications and conferences

Requirements

• Ph.D. in biostatistics, statistics, data science, or related quantitative field
• 2+ years relevant experience; 3-5 years ideal
• Proficiency in R and SAS; working knowledge of Python and machine-learning libraries
• Experience building data pipelines for high-dimensional and real-world datasets
• Ability to communicate complex analyses to non-statistical stakeholders
• Real-world data and regulatory guidelines experience preferred
• Multi-omic, PK/PD biomarker, and genomic dataset familiarity preferred

Compensation: $150,000 - $182,500 per year base salary

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